BioCos

Project: Establishment of an integrative nutrigenomics platform for End Stage Renal Disease patients

Nutrigenomics is fundamental in the understanding of the dietary intake influence on phenotype, particularly of the silver population. The project aims to establish an integrative nutrigenomics platform from silver population of End Stage Renal Disease (ESRD) patients from Crete (Greece). To achieve this, BioCos will integrate omics data and dietary habits from healthy and kidney-failure individuals in order to assess the molecular mechanisms interacting with bioactive compounds and nutrients and detect putative biomarkers.

Midway status 

The BioCos project is running on schedule. During the first phase, the team has collected and assessed nutritional status data from 45 hemodialysis patients with end stage renal disease, including investigations of anthropometry, body composition and dietary habits plus biochemical and proteomic analyses. This fulfils the aim of the first work package – to combine proteomic data with nutritional habits.

In the second phase, the team is examining transcriptomic REN-seq data obtained from the plasma of kidney patients and healthy subjects. The output of this analysis will be combined with the proteomic results of the first phase.

One in five people aged 65+ have chronic kidney disease. Nutrigenomics represents the key to unravelling the relationship between nutritional habits and the molecular mediators to a disease,” say the BioCos team.

  • Sectors involved: Health

  • Partner country: Greece

  • Voucher(s): Demonstration Voucher & International Property Rights Innovation Voucher

  • Part of consortium: Yes

About BioCos
BioCoS stands for “Bioinformatics and Computational Science” and their core business activity is to provide and commercialise Bioinformatic solutions in the biomedical and agri-food industry e.g., omics data, biomarkers, DNA traceabilty and authenticity of products.

Consortium

Sequentia Biotech SL
Sequentia is a bioinformatics company that offers services and technologies that help transform genomic data into knowledge in academic research, plant and animal breeding, and biomedicine.

Foundation for Research and Techonology – Hellas Institute of Molecular Biology and Biotechnology (IMBB-FORTH)
IMBB is one of the most prominent life science research institutions in Greece. IMBB’s main mission is to pursue cutting-edge research and promote scientific excellence.

Technological Educational Institute (T.E.I.) of Crete – Department of Nutrition & Dietetics
The T.E.I. of Crete is a Public Educational Institute founded in 1983. The Institute is a part of the higher education system of Greece and it provides undergraduate and postgraduate education services.